Coordination diversity in transition metal complexes with 4-aminoantipyrine tethered bis(imino)pyridine ligand: structures, superoxide dismutase and anticancer properties

Abstract

In this article, we report Mn(II), Fe(II) and Cu(I) complexes (BIP-Mn, BIP-Fe and BIP-Cu) bearing a non-innocent, NNN pincer ligand, 4-aminoantipyrine tethered 2,6-bis(iminoantipyrine)pyridine (BIP) and structural diversity. The complexes were characterized by different spectroscopic and single-crystal X-ray analysis. Superoxide dismutase (SOD) activity has been evaluated for BIP and complexes BIP-Mn, BIP-Fe and BIP-Cu. It was observed that the seven-coordinate BIP-Mn complex showed preeminent SOD activity on comparing to BIP-Fe and BIP-Cu complexes. Besides, preliminary in vitro anticancer properties of BIP-Mn, BIP-Fe and BIP-Cu have been studied. Again, BIP-Mn complex showed stronger anticancer activity compared to ligand, BIP-Fe and BIP-Cu complexes.