Advancing Ocular Drug Delivery: Sulfoxy Amine Xanthan Gum-Based Inserts

Abstract

Xanthan gum, a natural polysaccharide, is commonly used in pharmaceutical sciences for its biocompatibility and its mucoadhesive property. Recent modification in adding sulfoxy amine groups to xanthan gum have demonstrated potential activity in improving its efficacy in ocular drug delivery systems. The objective of this research is to develop and assess ocular inserts containing sulfoxy amine xanthan gum for sustained release of ciprofloxacin as a drug. Objectives: The objective of this study is to formulate and assess ocular inserts made with sulfoxy amine-modified xanthan gum, focusing on their properties, drug release pattern, and compatibility with the body. Methods: Xanthan gum is modified and successfully converted into sulfoxy amine xanthan gum. Ocular inserts films of Ciprofloxacin have been successfully formulated by solvent casting technique. The prepared films were evaluated in terms of physical appearance, surface pH, uniformity, and folding endurance. The method of preparation of ocular inserts is reproduced, and ocular inserts ensure excellent quality with uniformity of patch characteristics with minimum variability. Results: Xanthan gum-based ocular inserts containing sulfoxy amine demonstrated an appropriate film thickness and suitable folding endurance. The surface pH and weight uniformity of the ocular inserts also within acceptable ranges, supporting their suitability for sustained release of drug ciprofloxacin. Conclusion: The sulfoxy amine xanthan gum-based ocular inserts exhibited superior physiological properties, sustained drug release, and excellent biocompatibility, making them a promising candidate for ocular drug delivery systems. Further studies are needed to explore their potential in clinical settings.