HYALURONIC ACID/ POLYVINYL ALCOHOL ELECTROSPUN NANOFIBER WITH CURCUMIN NANOPARTICLES FOR WOUND DRESSINGS

Abstract

Abstract Introduction: PVA is a synthetic water-soluble polymer, widely used in biomedical and pharmaceutical applications because of its biocompatibility, biodegradability, and non-toxic properties. The presence of hydroxyl groups on PVA increases its hydrophilicity and capacity to create good physical/chemical interaction with other molecules. Hyaluronic acid helps skin stretch and flex and reduces skin wrinkles and lines. Hyaluronic acid is also proven to help wounds heal faster and can reduce scarring. Aim: To synthesize, characterise and check the biocompatibility of PVA/HA nanofiber membrane loaded with curcumin nanoparticles for wound dressing. Materials & methods: To create a nanofibrous mat from the mixture of PVA and curcumin at two different mixing ratios, two electrospinning solutions were made. Results: In our research the nanofibers made of PVA/HA - CURCUMIN had a good cell viability rate of 85% which makes us confirm that it is a good biocompatible substance. Conclusion: Our study proposes a method for the preparation of PVA/HA nanofiber membranes with good cytocompatibility and degradation resistance. Further studies should be done in animal model.