Two Bioactive Saponins from <i>Albizia </i><i>s</i><i>ubdimidiata </i>from the Suriname\nRainforest

Abstract

Bioassay-guided fractionation of a methanol extract of <i>Albizia </i><i>subdimidiata</i> using the engineered yeast\nstrains 1138, 1140, 1353, and Sc7 of<i> Saccharomyces cerevisiae</i> as the bioassay tool resulted in the isolation\nof the two active saponins <b>1 </b>and <b>2</b>; one of these, albiziatrioside A (<b>1</b>), is described for the first time. The\nstructures of <b>1 </b>and <b>2 </b>were established on the basis of HRMS, 1D and 2D NMR spectral data, and GC−MS analysis of the sugar units. Both isolated compounds showed significant cytotoxicity against the A2780\ncell line.