Photoresponsive Hydrogen-Bonded Organic Frameworks-Enabled\nOrganic Photoelectrochemical Transistors for Sensitive Bioanalysis

Abstract

A facile\nroute for exponential magnification of transconductance\n(<i>g</i>_m) in an organic photoelectrochemical\ntransistor (OPECT) is still lacking. Herein, photoresponsive hydrogen-bonded\norganic frameworks (PR-HOFs) have been shown to be efficient for <i>g</i>_m magnification in a typical poly(ethylene dioxythiophene):poly(styrenesulfonate)\nOPECT. Specifically, 450 nm light stimulation of 1,3,6,8-tetrakis\n(p-benzoic acid) pyrene (H4TBAPy)-based HOF could efficiently modulate\nthe device characteristics, leading to the considerable <i>g</i>_m magnification over 78 times from 0.114 to 8.96 mS at\nzero <i>V</i>_g. In linkage with a DNA nanomachine-assisted\nsteric hindrance amplification strategy, the system was then interfaced\nwith the microRNA-triggered structural DNA evolution toward the sensitive\ndetection of a model target microRNA down to 0.1 fM. This study first\nreveals HOFs-enabled efficient <i>g</i>_m magnification\nin organic electronics and its application for sensitive biomolecular\ndetection.