Fully\nStretchable Capillary Microfluidics-Integrated\nNanoporous Gold Electrochemical Sensor for Wearable Continuous Glucose\nMonitoring

Abstract

Biosensor\nsystems for wearable continuous monitoring are desired\nto be developed into conformal patch platforms. However, developing\nsuch patches is very challenging owing to the difficulty of imparting\nmaterials and components with both high stretchability and high performance.\nHerein, we report a fully stretchable microfluidics-integrated glucose\nsensor patch comprised of an omnidirectionally stretchable nanoporous\ngold (NPG) electrochemical biosensor and a stretchable passive microfluidic\ndevice. A highly electrocatalytic NPG electrode was formed on a stress-absorbing\n3D micropatterned polydimethylsiloxane (PDMS) substrate to confer\nmechanical stretchability, high sensitivity, and durability in non-enzymatic\nglucose detection. A thin, stretchable, and tough microfluidic device\nwas made by embedding stretchable cotton fabric as a capillary into\na thin polyurethane nanofiber-reinforced PDMS channel, enabling collection\nand passive, accurate delivery of sweat from skin to the electrode\nsurface, with excellent replacement capability. The integrated glucose\nsensor patch demonstrated excellent ability to continuously and accurately\nmonitor the sweat glucose level.