Solubility Enhancement of Poorly Water-Soluble Drugs: A Review

Chopde asha subhashrao, Dr. Manish Dubey

doi:10.5281/zenodo.16401036

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JOURNAL ARTICLE

Solubility Enhancement of Poorly Water-Soluble Drugs: A Review

Chopde asha subhashrao, Dr. Manish Dubey

Year: 2025 Journal: Zenodo (CERN European Organization for Nuclear Research) Publisher: European Organization for Nuclear Research

DOI: 10.5281/zenodo.16401036

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Abstract

Abstract Solubility is a critical factor in drug development, influencing drug absorption, bioavailability, and therapeutic efficacy. Poor aqueous solubility poses a significant challenge for the formulation of many pharmaceutical compounds, particularly for Biopharmaceutical Classification System (BCS) class II and IV drugs. This review explores various strategies to enhance the solubility of poorly water-soluble drugs, including physical, chemical, and advanced technological approaches.

Keywords:

Solubility Biopharmaceutical Pharmaceutical technology Drug Class (philosophy)

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Groundwater and Isotope Geochemistry

Physical Sciences → Earth and Planetary Sciences → Geochemistry and Petrology

Groundwater flow and contamination studies

Physical Sciences → Environmental Science → Environmental Engineering

Hydrology and Watershed Management Studies

Physical Sciences → Environmental Science → Water Science and Technology

Solubility Enhancement of Poorly Water-Soluble Drugs: A Review

Abstract

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