DNA-Decorated\nTwo-Dimensional Crystalline Nanosheets

Abstract

Design and synthesis of high aspect\nratio 2D nanosheets with surface\nhaving ultradense array of information-rich molecule such as DNA is\nextremely challenging. Herein, we report a universal strategy based\non amphiphilicity-driven self-assembly\nfor the crafting of high aspect ratio, 2D sheets that are densely\nsurface-decorated with DNA. Microscopy and X-ray analyses have shown\nthat the sheets are crystalline. The most unique feature of the sheets\nis DNA-directed surface addressability, which is demonstrated through\nthe decoration of either faces of the sheet with gold nanoparticles\nthrough sequence-specific DNA hybridization. Our results suggest that\nthis design strategy can be applied as a general approach for the\nsynthesis of DNA decorated high aspect ratio sheets, which may find\npotential applications in materials science, drug delivery, and nanoelectronics.