NIR-Triggered\nSequentially Responsive Nanocarriers\nAmplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy\nwith Inspired Antitumor Immunity

Abstract

A desirable cancer\ntherapeutic strategy is supposed to have effective\nability to not only exert maximum anticancer ability but also inspire\nantitumor immunity for preventing tumor relapse and metastasis. During\nthis research, multifunctional upconversion nanoparticles (UCNPs)\ncoated by ROS-responsive micelles are prepared for tumor targeting\nand near-infrared (NIR)-triggered photodynamic therapy (PDT)-combined\nsynergistic effect of chemotherapy. Moreover, both PDT and chemotherapy\nagents could activate antitumor immunity <i>via</i> inducing\nimmunogenic cell death with CD8⁺ and CD4⁺ T\ncells infiltrating in tumors. Through the experiments, intravenous\nadministration of multifunctional nanocarriers with noninvasive NIR\nirradiation destroys the orthotopic tumors and efficiently suppresses\nlung metastasis in a metastatic triple-negative breast cancer model\nby cascade-amplifying chemo-PDT and systemic antitumor immunity. In\nconclusion, this study provides prospective chemo-PDT with inspired\nantitumor immunity for metastatic cancer treatment.