Miniaturized Reverse Electrodialysis-Powered Biosensor\nUsing Electrochemiluminescence on Bipolar Electrode

Abstract

We\nsuggest an electrochemiluminescence (ECL)-sensing platform driven\nby ecofriendly, disposable, and miniaturized reverse electrodialysis\n(RED) patches as an electric power source. The flexible RED patches\ncomposed of ion-exchange membranes (IEMs) can produce voltage required\nfor ECL sensing by simply choosing the appropriate number of IEMs\nand the ratio of salt concentrations. We integrate the RED patch with\na bipolar electrode on the microfluidic chip to demonstrate the proof-of-concept,\ni.e., glucose detection in the range of 0.5–10 mM by observing\nECL emissions with naked eyes. The miniaturized RED-powered biosensing\nsystem is widely applicable for electrochemical-sensing platforms.\nThis is expected to be a solution for practical availability of battery-free\nelectrochemical sensors for disease diagnosis in developing countries.