pH Sensitive Hydrogel Based Controlled Drug Delivery System for Oral Delivery of Famotidine

Abstract

Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. A new pH responsive drug delivery system based on inter-polymeric hydrogels was developed for oral drug delivery of famotidine, the effect of various formulation variables i.e. concentration of crosslinking agent and polymer ratio were studies on entrapment efficiency, pH sensitive behavior, temperature sensitive swelling, % swelling, mucoadhesion and in-vitro drug release profile. For the development of hydrogel formulation, the % swelling and release of drug in plays an important role. The basis on optimize the formulation. In this the polymer and crosslinker concentration varying in different ratio.