Targeted drug delivery to the lungs using mesoporous silica nanoparticles

Abstract

Delivering drugs to tumour or defective cells effectively and efficiently while minimizing harmful side effects is one of the biggest issues facing the medical field. In order to address this issue, the pharmaceutical industry has developed a number of drug carriers that aid in getting the therapeutic medication or gene to the intended location. It has been discovered that mesoporous silica nanoparticles are biocompatible, chemically and thermally stable nanoparticles for this purpose the amount of research on MSNs has increased significantly in the last few years. Since 2001, when MCM-41 was first suggested as a drug carrier for a controlled delivery system, followed by SBA-15 and MCM-48. When changed, morphological features like pore size, pore volume, particle size, surface area, pH, and drug loading capacity have a significant impact on MSNs. Drug distribution to the intended place is elaborated by functionalizing MSNs with organic and inorganic groups. The most recent studies on MSN synthesis techniques and its uses in medical imaging, diagnostics, cellular uptake, target medication administration, cell tracing, and biosensing are also included in this review article.