Metal-Free Synthesis\nof Functionalized Indolizines\nvia a Cascade Michael/S_N2/Aromatization Reaction of 2‑Alkylazaarene\nDerivatives with Bromonitroolefins

Abstract

A transition metal-free domino Michael/S_N2/aromatization\nannulation of 2-pyridylacetates with bromonitroolefins has been developed.\nA wide range of substrates containing various substituted groups was\ncompatible with the present methodology and afforded functionalized\nindolizines with moderate to excellent yield (up to 99% yield). In\naddition, the potential practicality of the method stood out through\nscale-up reactions and further transformations to other valuable compounds.\nIn our view, this study is an essential complement for the rapid construction\nof indolizine derivatives through a metal-free strategy.