Three-dimensional\nSalphen-based Covalent–Organic\nFrameworks as Catalytic Antioxidants

Abstract

The\ndevelopment of three-dimensional (3D) functionalized covalent–organic\nframeworks (COFs) is of critical importance for expanding their potential\napplications. However, the introduction of functional groups in 3D\nCOFs remains largely unexplored. Herein, we report the first example\nof 3D Salphen-based COFs (3D-Salphen-COFs) and their metal-containing\ncounterparts (3D-M-Salphen-COFs). These Salphen-based COFs exhibit\nhigh crystallinity and specific surface area in addition to excellent\nchemical stability. Furthermore, the Cu­(II)-Salphen COF displays high\nactivity in the removal of superoxide radicals. This study not only\npresents a new pathway to construct 3D functionalized COFs but also\npromotes their applications in biology and medicine.