Stabilization of G-Quadruplex DNA and Inhibition of Telomerase Activity by\nSquare-Planar Nickel(II) Complexes
Julie E. Reed (2641087)Anna Arola Arnal (2641084)Stephen Neidle (9285)Ramón Vilar (2515441)
Abstract
Two new alkylamine-substituted nickel(II)−salphen complexes have been prepared and their interactions with DNA investigated. FRET studies have shown that these complexes have a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays have shown that these complexes inhibit telomerase at low micromolar concentrations.
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