Sesquiterpenes from <i>Thapsia </i><i>nitida</i> var. <i>meridionalis</i> and <i>Thapsia </i><i>nitida</i> var. <i>nitida</i>
Juan J. Rubal (2518279)Francisco M. Guerra (1479439)F. Javier Moreno-Dorado (1479442)Zacarías D. Jorge (2518273)Guillermo M. Massanet (1479436)Helmer Søhoel (2518270)Ulla W. Smitt (2518276)Karla Frydenvang (1435294)S. Brøgger Christensen (1960330)Charlotte Nielsen (2518285)Margit Eriksson (2518282)
Abstract
Nine new eudesmanolides (<b>1</b>−<b>9</b>), two new guaianolides (<b>12</b> and <b>13</b>), and a new germacrane (<b>10</b>), along with a previously\nreported guaianolide (<b>11</b>), have been isolated from the roots of <i>Thapsia nitida</i> var. <i>meridionalis</i>. <i>Thapsia nitida var</i>.\n<i>nitida</i> also afforded compound <b>13</b> along with a new guaianolide (<b>14</b>). The structure of <b>13</b> was confirmed by X-ray\ncrystallographic analysis. Compounds <b>1</b>, <b>2</b>, and <b>11</b>−<b>14</b> have been tested as potential inhibitors of the sarco- and\nendoplasmic Ca<sup>2+</sup>-dependent ATPases (SERCA) pump. None of them showed significant activities.
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