Polyacetylenic Oleanane-Type Triterpene Saponins from\nthe Roots of <i>Panax japonicus</i>

Abstract

Three new polyacetylenic oleanane-type\ntriterpenoids, baisanqisaponins\nA–C (<b>1</b>–<b>3</b>), and one new oleanane-type\ntriterpenoid, chikusetsusaponin-V ethyl ester (<b>4</b>), together\nwith 19 known compounds (<b>5</b>–<b>23</b>), were\nisolated from the roots of <i>Panax japonicus</i>. The structures\nwere elucidated on the basis of spectroscopic analyses and chemical\nmethods. Compounds <b>1</b>–<b>3</b> feature a\nrare panaxytriol group containing a polyacetylene on the saponin skeleton.\nNeuroprotective activity was evaluated for compounds <b>1</b>–<b>17</b>, and angiotensin II-induced vascular smooth\nmuscle cell proliferation inhibition was tested for compounds <b>5</b>–<b>7</b> and <b>10</b>–<b>12</b>.