Self-Assembly MoS<sub>2</sub>@MnO<sub>2</sub> Nanoflowers\nfor the Fluorescence/Magnetic Resonance Dual-Modal Sensing of H<sub>2</sub>O<sub>2</sub> and Photothermal Therapy
Yongjian Lin (5009537)Xueqin Huang (12305221)Liping Hu (172765)Hanlin Zhou (9044141)Annan Yang (844721)Jun Xu (45543)Weijian Chen (4059265)Xueyi Zeng (11020533)Pinghua Sun (550477)Xing Zhong (54358)Haibo Zhou (575077)Huaihong Cai (817620)
Abstract
The functions of bioimaging and photothermal therapy\nintegrated\ninto a theranostic nanosystem to prove its diagnostic and therapeutic\ncapabilities are desirable. The versatile molybdenum disulfide (MoS<sub>2</sub>) dots doped with manganese dioxide (MnO<sub>2</sub>) nanoflowers\n(MoS<sub>2</sub>@MnO<sub>2</sub> NFs) were designed for the dual-modal\nfluorescence/magnetic resonance (MR) sensing/imaging of intracellular\nH<sub>2</sub>O<sub>2</sub>, as well as thermal/MR imaging-guided photothermal\ntherapy <i>in vivo</i>. The MnO<sub>2</sub> nanosheets in\nMoS<sub>2</sub>@MnO<sub>2</sub> NFs acted as an H<sub>2</sub>O<sub>2</sub>-mediated initiator, exhibiting fluorescence recovery and\nMn<sup>2+</sup>-related MR signal enhancement through specific H<sub>2</sub>O<sub>2</sub>-induced MnO<sub>2</sub> sheet degradation. Under\nthe optimal experimental conditions, a dual-modal fluorescence/MR\nsensor was used to quantitatively detect and image H<sub>2</sub>O<sub>2</sub> and intracellular H<sub>2</sub>O<sub>2</sub>, with a limit\nof detection (LOD) of 0.09 μM. Simultaneously, thermal-responsive\nMoS<sub>2</sub>@MnO<sub>2</sub> NFs showed robust photothermal cytotoxicity\ntoward cancer cells upon near-infrared (NIR) irradiation, allowing\nit to serve as a therapeutic drug for thermal/MR imaging-guided photothermal\ntherapy <i>in vivo</i>. This integrated theranostic nanosystem\ndemonstrated its power for multimodal bioimaging and enhanced therapeutic\ntherapy while reducing biotoxicity in mice.
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