Multicomponent Reactions: An Advanced Tool for Organic Synthesis

Abstract

Abstract: In organic synthesis, multicomponent reactions (MCRs) have become an effective tool for the synthesis of complex molecules from simple starting materials in a single operation. This review mainly focuses on the key features aligned with green chemistry principles, applications, and challenges associated with the MCRs. The application of MCRs is discussed in different fields, which include the synthesis of natural products, agrochemicals, material science, and pharmaceutical industries. It also covers the difficulties, including the optimization of reaction conditions, selectivity, and scalability of the multicomponent reactions.