Creating Patterned Poly(dimethylsiloxane) Surfaces with Amoxicillin\nand Poly(ethylene glycol)

Abstract

This paper reports a simple microwave plasma patterning of poly(dimethylsiloxane) (PDMS) surfaces, which is\naccomplished by allowing selective surface areas to microwave plasma exposure in the presence of gaseous monomer.\nWhen maleic anhydride is used for microwave plasma reaction in the presence of physical barrier on the PDMS\nsubstrate, the resulting patterned surfaces with chemically bonded maleic anhydride and carboxylic acid groups are\ngenerated. In this particular study we attached amoxicillin via ammonolysis under weak base conditions in the presence\nof a catalyst as well as poly(ethyleneglycol) (PEG). A combination of internal reflection IR imaging (IRIRI) and atomic\nforce microscopy (AFM) revealed that amoxicillin and PEG can be readily reacted on the microwave plasma patterned\nPDMS surfaces. Surface areas directly exposed to microwave plasmons exhibit the highest reactivity due to higher\ncontent of functional groups. These studies also show that molecular weight of PEG has also significant effect on\nkinetics of surface reactions.