Palladium-Catalyzed One-Pot Synthesis of\n2-Alkyl-2-arylcyanoacetates
Xiang Wang (127867)Anil Guram (2216815)Emilio Bunel (2454523)Guo-Qiang Cao (2412940)Jennifer R. Allen (1693594)Margaret M. Faul (1804996)
Abstract
A one-pot procedure for the synthesis of 2-alkyl-2-arylcyanoacetates based on a Pd(OAc)<sub>2</sub>/DPPF (DPPF = 1,1‘-diphenylphosphino ferreocene)-catalyzed enolate arylation\nfollowed by in situ alkylation has been developed. This\nprocedure tolerates a diverse range of aryl and heteroaryl\nbromides, and provides a rapid entry to a variety of 2-alkyl-2-arylcyanoacetates in good to excellent yield.
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