Abstract The Whole Health APRN (advanced practice registered nurse) Model embraces the synergy of integrative nursing and functional medicine to provide a structure for the practical clinical application of advanced practice integrative nursing. The model guides assessment and can be used within primary care or any specialty care setting to promote whole health. When an integrative APRN owns their unique skillset and uses this model, it results in an advanced approach to symptom management, and there are even greater possibilities to deliver the transformative whole health care that patients want and that the healthcare system needs.