Advanced Techniques in Solubility Enhancement of Poorly Water-Soluble Drugs

Abstract

Solubility is the essential ability of any solute to be dissolved in any solution at different parameters. It has been evaluated that, about 30-50% of medicaments have poor solubility and dissolution rate. One of the key factors influencing a drug's bioavailability and pharmacokinetics is its solubility. These poorly soluble drugs can lead to gastro intestinal, mucosal toxicity and reduced pharmacological action. It is among the most significant issues encountered during the planning and creation of NCEs. The Biopharmaceutical Classification System [BCS] is known as the highly advanced methodology to differentiate the drug substances on the basis of their Solubility and Permeability. This methodology is widely used for management in the early development process of medications and in the identification of NCEs along with drug discovery process. Currently, there are several techniques used for enhancing aqueous solubility of drugs for greater bioavailability and increased therapeutics. Throughout the decade, various traditional approaches have been utilised to enhance the solubility of medicinal compounds.