Gastrodin ameliorates DSS-induced ulcerative colitis via enhancing the abundance of Akkermansia muciniphila and modulating the metabolites

Abstract

G. elata ameliorated colitis through a novel 'herbal monomer‒microbiota‒metabolite' axis, enriching A. muciniphila and enhancing the levels of key anti-inflammatory metabolites. These findings provided evidence the traditional application of G. elata and its active ingredient GAS as a promising microbiota-targeting therapy for UC.