Preconditioning donor lungs with lung-derived exosomes mitigates ischemia-reperfusion injury in a warm ischemia porcine DCD model

Rafaela Vanin Pinto Ribeiro; Salah E. Altarabsheh; Daemiel L Segamanasinghe; Ismar W Lopez-Muralles; A. Moreno; Gustavo L. Knop; Fu’ad Al-Azzam; Jorge M. Mallea; Douglas Brownfield; A.L. Olson; D. Gibbard; Yujia Jing; Ke Cheng; Sahar A. Saddoughi

doi:10.1016/j.healun.2025.03.018

JOURNAL ARTICLE

Preconditioning donor lungs with lung-derived exosomes mitigates ischemia-reperfusion injury in a warm ischemia porcine DCD model

Rafaela Vanin Pinto Ribeiro Salah E. Altarabsheh Daemiel L Segamanasinghe Ismar W Lopez-Muralles A. Moreno Gustavo L. Knop Fu’ad Al-Azzam Jorge M. Mallea Douglas Brownfield A.L. Olson D. Gibbard Yujia Jing Ke Cheng Sahar A. Saddoughi

Year: 2025 Journal: The Journal of Heart and Lung Transplantation Vol: 44 (7)Pages: 1149-1160 Publisher: Elsevier BV

DOI: 10.1016/j.healun.2025.03.018

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Keywords:

Microvesicles Ischemia Reperfusion injury Lung Medicine Warm ischemia Pharmacology Anesthesia Cardiology Internal medicine Chemistry microRNA Biochemistry

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Topics

Transplantation: Methods and Outcomes

Health Sciences → Medicine → Surgery

Extracellular vesicles in disease

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Organ Transplantation Techniques and Outcomes

Health Sciences → Medicine → Surgery

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