Hypoxia-induced PRPF19 modulates TPT1 alternative splicing to facilitate cisplatin resistance in high-grade serous ovarian cancer

Wei Wei; Yang Zhang; Yibing Li; Jiazhen Huang; Fuli Kang; Shuang Tan; Lin Lin; Xiaohang Lu; Heng Wei; Ning Wang

doi:10.1016/j.bbadis.2025.167721

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Hypoxia-induced PRPF19 modulates TPT1 alternative splicing to facilitate cisplatin resistance in high-grade serous ovarian cancer

Wei Wei Yang Zhang Yibing Li Jiazhen Huang Fuli Kang Shuang Tan Lin Lin Xiaohang Lu Heng Wei Ning Wang

Year: 2025 Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Vol: 1871 (4)Pages: 167721-167721 Publisher: Elsevier BV

DOI: 10.1016/j.bbadis.2025.167721

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Keywords:

Serous ovarian cancer Ovarian cancer Cisplatin Serous fluid Hypoxia (environmental) Medicine Oncology Internal medicine Cancer research Chemistry Cancer Chemotherapy Oxygen

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RNA modifications and cancer

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

RNA Research and Splicing

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Cancer-related molecular mechanisms research

Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research

Hypoxia-induced PRPF19 modulates TPT1 alternative splicing to facilitate cisplatin resistance in high-grade serous ovarian cancer

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