Histopathological and biochemical impacts of aqueous Carica papaya leaf extract on the liver of streptozotocin-induced diabetic Albino Rats

Abstract

This study was conducted to examine the effects of an aqueous extract of Carica papaya leaf on the liver of a wistar rat that had been streptozotocin-induced diabetic. For this investigation, one hundred (100) male wistar rats weighing between 200 and 300g were employed. They were split up into five groups of twenty rats each (I, II, III, IV, and V). Group I was used as a non-diabetic control, whereas Groups II, III, IV, and V received intraperitoneal injections of 60 mg/kg streptozotocin freshly dissolved in 0.1M citrate buffer (pH 4.5) at a volume of 1 ml/kg body weight in order to induce diabetes. Groups III, IV, and V received freshly made aqueous extract of Carica papaya leaves at a rate of 0.75g/kg body weight, 1.5g/kg body weight, and 3g/kg body weight, respectively. Diabetes control was provided by Group II, whereas non-diabetic control was provided by Group I. At baseline and throughout the course of treatment, weight and blood glucose levels were also recorded. The liver histology section of diabetic rats given 1.5 and 3.0 grams per kilogram of body weight. The aqueous extract of Carica papaya leaves improved the hepatic morphological disruption caused by induced diabetes, which in turn improved the hepatic histoarchitecture. Liver impairment was also detected by the biochemistry of the liver enzymes. Compared to rats that were not treated, diabetic rats treated with aqueous Carica papaya showed a substantial decrease (p<0.05) in the biomarkers ALT, AST, and ALP. According to the study's findings, adult wistar rats with diabetes induced by streptozotocin showed less liver damage when given an aqueous extract of Carica papaya leaves.