JOURNAL ARTICLE
6H-Indolo-[2,3-b]-quinoxaline derivatives as promising bifunctional SHP1 inhibitors
Chun ZhangYi-Xin DongLixin GaoSuya GanWenran GaoJia LiDa-Jun XiangXin WangYubo ZhouWenlong Wang
Year: 2024 Journal: Organic & Biomolecular Chemistry Vol: 23 (6)Pages: 1394-1405 Publisher: Royal Society of Chemistry
Abstract
A bifunctional indoloquinoxaline derivative 5a was synthesized via a structural fusion and scaffold hop strategy, and exhibits SHP1 inhibitory activity (IC 50 : 2.34 ± 0.06 μM) whilst being capable of blue/green cellular imaging.
Keywords:
Quinoxaline Bifunctional Chemistry Combinatorial chemistry Organic chemistry
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Citation History
Topics
Synthesis and Biological Evaluation
Physical Sciences → Chemistry → Organic Chemistry
Synthesis and biological activity
Physical Sciences → Chemistry → Organic Chemistry
Bioactive Compounds and Antitumor Agents
Life Sciences → Pharmacology, Toxicology and Pharmaceutics → Toxicology
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