MEASUREMENT OF APPARENT DIFFUSION COEFFICIENT IN NORMAL PROSTATE GLAND

Abstract

Motivation: The prostate gland consist of 3 distinctive zones, namely Central zone (CZ), Transitional Zone (TZ), and Peripheral Zone (PZ) having diffusive property, which can be measured by apparent diffusion coefficient (ADC) . Goal(s): This study aims to measure ADC values of the prostate with age that varies according to tissue density. Approach: A retrospective cross-sectional study with a purposive sampling technique was conducted on 25 patients with ages ranging from 20-90 years with no history of prostatic disease. Results: Age related decrease in ADC value were observed in this study with significant difference in ADC values between zones of prostate. Impact: when using DWI for diagnosing prostate cancer, age-related changes in ADC value need to be considered. Increase in age have influence in ADC value of different zones showing significant differences, with highest in PZ and lowest in CZ.