Targeting Tumor Microenvironment for Advanced Cancer Therapy

Abstract

The tumor microenvironment (TME) has emerged as a pivotal determinant in the progression of cancer and the development of resistance to therapeutic interventions. The heterogeneous cellular composition of the TME not only facilitates tumor proliferation but also poses formidable obstacles to the efficacy of conventional treatments. This chapter delves into an examination of the distinctive attributes of the TME, exploring both established and innovative approaches designed to target the TME. Through a thorough analysis of the intricate involvement of the TME in cancer biology, we underscore the imperative for a comprehensive understanding and specific modulation of the TME to enhance the efficacy of cancer treatments. This elucidation provides novel insights for further research endeavors and clinical applications.