Improving Computer-aided Detection for Digital Breast Tomosynthesis by Incorporating Temporal Change

Abstract

Purpose To develop a deep learning algorithm that uses temporal information to improve the performance of a previously published framework of cancer lesion detection for digital breast tomosynthesis. Materials and Methods This retrospective study analyzed the current and the 1-year-prior Hologic digital breast tomosynthesis screening examinations from eight different institutions between 2016 and 2020. The dataset contained 973 cancer and 7123 noncancer cases. The front end of this algorithm was an existing deep learning framework that performed single-view lesion detection followed by ipsilateral view matching. For this study, PriorNet was implemented as a cascaded deep learning module that used the additional growth information to refine the final probability of malignancy. Data from seven of the eight sites were used for training and validation, while the eighth site was reserved for external testing. Model performance was evaluated using localization receiver operating characteristic curves. Results On the validation set, PriorNet showed an area under the receiver operating characteristic curve (AUC) of 0.931 (95% CI: 0.930, 0.931), which outperformed both baseline models using single-view detection (AUC, 0.892 [95% CI: 0.891, 0.892]; P < .001) and ipsilateral matching (AUC, 0.915 [95% CI: 0.914, 0.915]; P < .001). On the external test set, PriorNet achieved an AUC of 0.896 (95% CI: 0.885, 0.896), outperforming both baselines (AUC, 0.846 [95% CI: 0.846, 0.847]; P < .001 and AUC, 0.865 [95% CI: 0.865, 0.866]; P < .001, respectively). In the high sensitivity range of 0.9 to 1.0, the partial AUC of PriorNet was significantly higher (P < .001) relative to both baselines. Conclusion PriorNet using temporal information further improved the breast cancer detection performance of an existing digital breast tomosynthesis cancer detection framework. Keywords: Digital Breast Tomosynthesis, Computer-aided Detection, Breast Cancer, Deep Learning © RSNA, 2024 See also commentary by Lee in this issue.