High Resolution Luminal Water Imaging for Prostate Cancer Diagnosis and Grading

Abstract

Current prostate cancer diagnosis and grading techniques have several limitations, which dictates further endeavors toward developing a more accurate approach. Luminal water imaging (LWI) has demonstrated superior diagnostic accuracy than the current multiparametric MRI standardized protocol. In this new application, we further optimized LWI acquisition by decreasing the in-plane resolution without sacrificing SNR by applying two different reduced field-of-view techniques. Our new sequences provide improved in-plane resolution to delineate anatomical details and provide high-quality data for LWI analysis. This new LWI acquisition could replace the lengthy multiparametric MRI that suffers from technical challenges, inferior diagnosis accuracy, and a required contrast agent injection compared to LWI.