POLYMERIC NANOPARTICLES FOR TARGETED DRUG DELIVERY

Abstract

Polymeric nanoparticles are found to have high potential for drug delivery for the treatment of various diseases. Polymeric materials are suitable for drug delivery because of their high possibilities of surface modifications. Polymeric micelles, dendrimers, and vesicles etc. are used for polymeric drug delivery. Polymeric nanoparticles (NPs) have attracted considerable interest over recent years due to their properties resulting from their small size. Advantages of polymeric NPs as drug carriers include their potential use for controlled release, the ability to protect drug and other molecules with biological activity against the environment, improve their bioavailability and therapeutic index. The term “nanoparticle” comprises both nanocapsules and nanospheres, which differ with respect to their morphology. Because of their gene loading capacity, stability and tunable properties polymeric materials have emerged as potential carrier in formulating a efficient gene delivery system. To ensure appropriate release of the gene as well as easy removal of the carrier after gene release, selection of polymeric materials is vital. Polymeric-based nanoparticles have an incredible potential to combat the novel coronavirus illness (COVID-19) due to their intrinsic competitive advantages. Polymeric Nanoparticle because of their small size, have distinct properties compared to the bulk form of the same material, thus offering many new developments in the fields of biosensors, biomedicine, and bio nanotechnology. In this review article we have mainly discussed about the application of polymeric nanoparticles in the field of drug delivery for various common diseases.