Oncolytic Virotherapy in Breast Cancer

Abstract

Breast cancer has a high incidence and fatality rate, making it a major worldwide health problem. Traditional treatment methods, treatments including chemotherapy, radiation therapy, and surgery, are partially effective in treating advanced breast cancer. Oncolytic viruses are a class of viruses with potential antitumor activity, demonstrating significant promise in cancer therapy through targeted invasion and elimination of tumor cells. In recent years, oncolytic virus therapy and its combination treatments have shown promise in the treatment of breast cancer. This review explores the potential applications of oncolytic viruses, including adenovirus, herpes simplex virus, and vaccinia virus, in breast cancer treatment. The effectiveness, safety, and methods of action of various viruses are covered in the article, as well as the achievements and progress in current research. The objective of this article is to elucidate the advantages of existing oncolytic therapies and inspire the development of novel strategies for treating breast cancer by enhancing understanding and utilization of oncolytic virus therapy. It seeks to harness the potential of new technologies to benefit patients.