JOURNAL ARTICLE

Oleanane‐Type Triterpene Glycosides from Camellia phanii and Their α‐Glucosidase Inhibitory Activity

Abstract

Abstract Three new oleanane‐ type triterpene saponins, named camphanosides A–C ( 1 – 3 ), along with five known compounds, chikusetsusaponin IVa ( 4 ), spinasaponin A 28‐ O ‐glucoside ( 5 ), (−)‐epicatechin ( 6 ), (−)‐epicatechin 3‐ O ‐gallate ( 7 ), and (−)‐epigallocatechin 3‐ O ‐gallate ( 8 ) were isolated from the leaves Camellia phanii Hakoda & Ninh. Their structures were established by 1D and 2D‐NMR and mass spectral analysis and chemical methods. Moreover, compounds 1 – 5 were also evaluated for α ‐glucosidase inhibitory activity. Compounds 1 – 3 exhibited moderate α ‐glucosidase inhibitory activity with IC 50 values of 230.7±18.0, 251.4±22.7, and 421.4±25.6 μ M, respectively.

Keywords:
Triterpene Chemistry Oleanane Glycoside Stereochemistry Inhibitory postsynaptic potential Camellia Terpene Traditional medicine Botany Biology

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Citation History

Topics

Natural product bioactivities and synthesis
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology
Phytochemistry and Biological Activities
Life Sciences →  Agricultural and Biological Sciences →  Plant Science
Phytochemicals and Antioxidant Activities
Health Sciences →  Medicine →  Biochemistry
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