MP21-19 ESTABLISHING REFERENCE STIFFNESS VALUES OF THE NORMAL PEDIATRIC TESTIS USING SHEAR-WAVE ELASTOGRAPHY

Abstract

You have accessJournal of UrologyPediatrics II (MP21)1 May 2024MP21-19 ESTABLISHING REFERENCE STIFFNESS VALUES OF THE NORMAL PEDIATRIC TESTIS USING SHEAR-WAVE ELASTOGRAPHY Megan Escott, Abinav Udaiyar, Robert R. Wilson, Janmejay Hingu, Stanley Kogan, Marc Colaco, Marshal Schwartz, Steve Hodges, Anthony Atala, David Childs, Hooman Sadri-Ardekani, and Nicholas A. Deebel Megan EscottMegan Escott , Abinav UdaiyarAbinav Udaiyar , Robert R. WilsonRobert R. Wilson , Janmejay HinguJanmejay Hingu , Stanley KoganStanley Kogan , Marc ColacoMarc Colaco , Marshal SchwartzMarshal Schwartz , Steve HodgesSteve Hodges , Anthony AtalaAnthony Atala , David ChildsDavid Childs , Hooman Sadri-ArdekaniHooman Sadri-Ardekani , and Nicholas A. DeebelNicholas A. Deebel View All Author Informationhttps://doi.org/10.1097/01.JU.0001008844.84871.17.19AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Shear-wave elastography (SWE) is a non-invasive technique that quantifies tissue elasticity using sonography. Previous studies have aimed to define standard testicular elastography values in pediatric populations but are limited by small sample sizes or age ranges. Here, we report the largest normal testicular SWE evaluation cohort in pediatric patients under ten and ages 10 to 18. We aim to determine standard normal ranges in both pre-pubertal and pubertal patients. METHODS: Patients from one clinic location were screened for the IRB-approved study. Volunteers with no known history of testicular diseases, sex chromosome abnormalities, or testicular surgery were eligible. They underwent both testes' routine B-mode sonography and simultaneous multi-frame shear-wave elastography. Elastography measurements (kPa and m/s) were acquired at each testicle's superior, mid, and inferior poles. RESULTS: 178 testicles of 89 volunteers (mean age: 6.49±4.91, range: 2 months – 18 years) were measured. For analysis, participants were divided into two age groups: 2 months – 9 years (n=60) and 10 – 18 years (n=29). The average overall testicular elastography measurements significantly differed between the two age cohorts (4.73 kPa vs 4.02 kPa, p=0.03 and 1.22 m/s vs. 1.12 m/s, p=0.02). Additionally, there were statistically significant differences between the average elastography measurements of the mid poles (4.59 kPa vs. 3.69 kPa, p=0.02 and 1.21 m/s vs. 1.07 m/s, p=0.004) and lower poles (4.90 kPa vs 4.04 kPa, p=0.03 and 1.23 m/s vs. 1.14 m/s, p<0.05) in participants under ten compared to participants 10 and older. Table 1 reports the ranges of elastography measurements acquired in the two age cohorts. CONCLUSIONS: We established standard values of testicular stiffness in the largest cohort of normal pre-pubertal and pubertal pediatric patients to date. Prior work has investigated SWE's utility in evaluating pediatric testicular pathologies, such as undescended testes. Therefore, future work is needed to validate these measurements further to improve the utility of their clinical applications in evaluating childhood testicular disorders. Source of Funding: Institutional (Internal) Funding © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e337 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Megan Escott More articles by this author Abinav Udaiyar More articles by this author Robert R. Wilson More articles by this author Janmejay Hingu More articles by this author Stanley Kogan More articles by this author Marc Colaco More articles by this author Marshal Schwartz More articles by this author Steve Hodges More articles by this author Anthony Atala More articles by this author David Childs More articles by this author Hooman Sadri-Ardekani More articles by this author Nicholas A. Deebel More articles by this author Expand All Advertisement PDF downloadLoading ...