Zeolitic imidazolate framework 8 (ZIF-8) as sensing material for electrochemical detection of dopamine

Abstract

Abnormal levels of dopamine have been linked to several neurodegenerative conditions, including Parkinson, schizophrenia, bipolar, and Alzheimer. Dopamine detection is needed for monitoring and early detection of these diseases. An electrochemical sensor was fabricated by employing zeolitic imidazolate framework 8 to modify the surface of the glassy carbon electrode (ZIF-8/GCE). ZIF-8 was synthesized via a precipitation method performed at room temperature. Material characterization was conducting using scanning electron microscopy (SEM) and X-Ray Diffraction (XRD) revealing that ZIF-8 had uniform polyhedral shapes and the crystallinity of ZIF-8 was very high. Furthermore, the sensing performance of the modified electrode was evaluated using cyclic voltammetry (CV) and Different Pulse Voltammetry (DPV). The CV voltammograms showed that ZIF-8/GCE was able to oxidize and enhanced oxidation-reduction activity of dopamine in phosphate buffer saline (pH 7.4) compared to bare GCE. The DPV results showed that the sensitivity and Limit of Detection (LOD) of the sensor were 0.0714 µA/μM and 0.108 µM, respectively.