Recent advances in dendrimer-based drug and gene delivery system

Abstract

Drug delivery technologies play a pivotal role in optimizing the therapeutic potential of pharmaceutical compounds. Despite the significant advancements, efficient targeted drug delivery remains a complex task. Nano-materials, with their tuneable physicochemical properties, provide a versatile platform for encapsulating and delivering a wide range of therapeutic agents. Among various nano-materials, dendritic nanostructures have appealed focus of researchers for their distinctive structural properties. Dendrimers are well-defined homogenous three-dimensional structures of nano-dimension resembling tree-like branches which have been investigated for combination therapy, where multiple therapeutic agents can be simultaneously delivered, promoting synergistic effects and reducing the development of drug resistance. The advancements in nanotechnology have facilitated the integration of dendrimers with various imaging modalities, enabling theranostic applications that combine drug delivery with real-time monitoring of treatment efficacy. The recent breakthroughs in dendrimer-based drug delivery have demonstrated their potential to revolutionize the pharmaceutical industry by holding promise for personalized medicine, targeted therapy, and improved patient outcomes in the future. However, further studies are been done to address biocompatibility, toxicity concerns, and scalability for successful translation from the laboratory to clinical applications. The study presented here describes the dendrimer's structures and its remarkable properties that open doors to a myriad of possibilities, promising to reshape medicine, technology, and the environment for the betterment of humanity.