JOURNAL ARTICLE

MSC-Derived Exosomes Mitigate Myocardial Ischemia/Reperfusion Injury by Reducing Neutrophil Infiltration and the Formation of Neutrophil Extracellular Traps

Yuting FengXue BaoJinxuan ZhaoLina KangXuan SunBiao Xu

Year: 2024 Journal:   International Journal of Nanomedicine Vol: Volume 19 Pages: 2071-2090   Publisher: Dove Medical Press

Abstract

Our results demonstrated that MSC-Exo mitigated myocardial I/R injury in mice by modulating neutrophil infiltration and NETs formation. This study provides novel insights into the potential therapeutic application of MSC-Exo for myocardial ischemia/reperfusion injury.

Keywords:
Neutrophil extracellular traps In vivo Infiltration (HVAC) Inflammasome Exosome Microvesicles Reperfusion injury Inflammation In vitro Medicine Flow cytometry Mesenchymal stem cell Extracellular Ischemia Pharmacology Immunology Chemistry Pathology Biology Internal medicine microRNA Biochemistry

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32
Cited By
15.32
FWCI (Field Weighted Citation Impact)
36
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0.98
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Citation History

Topics

Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences →  Immunology and Microbiology →  Immunology
Extracellular vesicles in disease
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology
S100 Proteins and Annexins
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology

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