Non-enzymatic glucose detection via electrochemical methods using copper-based metal-organic frameworks

Abstract

This study introduces a novel approach for the non-enzymatic electrochemical detection of glucose using copper-based metal-organic frameworks (Cu-MOFs). Recognizing the limitations of conventional enzymatic glucose sensors, such as sensitivity to environmental conditions and high costs, we explore the potential of Cu-MOFs as a robust and cost-effective alternative. Cu-MOFs, known for their high surface area and catalytic properties, are synthesized and applied as the active material in an electrochemical sensor. The sensor's performance is evaluated in terms of sensitivity, selectivity, response time, and stability under various conditions. Experimental results demonstrate that the Cu-MOF-based sensor exhibits a significantly enhanced electrocatalytic activity towards glucose oxidation, resulting in a high sensitivity and a wide linear range of detection. The sensor also shows good selectivity against common interfering substances, making it suitable for practical applications. This study's findings suggest that Cu-MOFs offer a promising pathway for developing efficient and reliable glucose monitoring systems, potentially transforming diabetes management and other healthcare applications.