Adenine–adenine, adenine–cytosine and cytosine–cytosine intrastrand crosslinks induced by a photoactivatable Pt(<scp>iv</scp>) anticancer prodrug

Jiafan Lin; Jingjing Huang; Jishuai Zhang; Xinrui Qin; Ziqi Ma; Xiaoqin Wu; Fuyi Wang; Yao Zhao; Kui Wu

doi:10.1039/d3dt03351a

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Adenine–adenine, adenine–cytosine and cytosine–cytosine intrastrand crosslinks induced by a photoactivatable Pt(iv) anticancer prodrug

Jiafan Lin Jingjing Huang Jishuai Zhang Xinrui Qin Ziqi Ma Xiaoqin Wu Fuyi Wang Yao Zhao Kui Wu

Year: 2023 Journal: Dalton Transactions Vol: 53 (1)Pages: 292-298 Publisher: Royal Society of Chemistry

DOI: 10.1039/d3dt03351a

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Abstract

Mass spectrometric analysis revealed the 1,3-ATA/ATC/CTA/CTC crosslinks in trinucleotides by trans -[Pt II (py) 2 ] 2+ from a photoactivatable diazido Pt( iv ) anticancer prodrug upon irradiation.

Keywords:

Chemistry Cytosine Adduct Stereochemistry Prodrug Electrospray ionization DNA Pyridine Mass spectrometry Medicinal chemistry Biochemistry Organic chemistry

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Metal complexes synthesis and properties

Health Sciences → Medicine → Oncology

Advanced biosensing and bioanalysis techniques

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

DNA and Nucleic Acid Chemistry

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Adenine–adenine, adenine–cytosine and cytosine–cytosine intrastrand crosslinks induced by a photoactivatable Pt(iv) anticancer prodrug

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