Web Alert: Marine Microbial Natural Products

Abstract

CMNPD Database https://www.cmnpd.org The Comprehensive Marine Natural Products Database (CMNPD) is an open-access resource focussed on marine natural products research. Screening using the CMNPD https://www.mdpi.com/2075-1729/13/6/1298 This paper describes in silico screening methods for identifying acetylcholinesterase inhibitors using the Comprehensive Marine Natural Products Database (CMNPD). MarinLit https://marinlit.rsc.org MarinLit is a site dedicated to literature and compound information related to marine natural products research. Marine natural product databases https://onlinelibrary.wiley.com/doi/full/10.1002/biot.201800607 This review article highlights dedicated and tangentially related databases that could prove useful for those studying marine natural products. It focusses on freely available resources. PeruNPDB https://www.biorxiv.org/content/10.1101/2023.01.15.524152v1 This preprint describes an effort to focus on local marine natural products of Peru. Similar efforts are ongoing for Mexico, Brazil, India and China. Marine natural products in clinical use https://pubmed.ncbi.nlm.nih.gov/36005531/ Only a limited number of marine natural products reach the clinical stage of development, and this review focusses on those. Antifouling marine natural products https://www.frontiersin.org/articles/10.3389/fmars.2022.858757/full Society invests considerable resources in preventing the build-up of marine life on ships, harbour docks and offshore installations, often using toxic agents such as tributyltin. This article advocates for the use of biological controls to the problem. Marine natural products at Scripps https://scripps.ucsd.edu/research/topics/natural-products-chemistry Studies on marine natural products are highlighted by this webpage offered by the Scripps Institution of Oceanography and the University of California at San Diego. Marine natural products catalogue https://www.medchemexpress.com/NaturalProducts/marine-natural-products.html This commercial site offers a collection of marine natural products that may be purchased for screening purposes. Marine natural products GRC https://www.grc.org/marine-natural-products-conference/2024/ Gordon Research Conferences discuss cutting edge research in different fields and this one to be held in 2024 focusses on marine natural products. Marine natural product databases https://d4-pharma.com/marine-natural-products-database-for-drug-discovery/ This blog post describes the creation of a data compilation from more than 20,000 articles dealing with marine natural products. Sustainable production of marine natural products https://www.frontiersin.org/articles/10.3389/fmars.2023.1188090/full This is an Editorial article highlighting different papers submitted for a Frontiers special issue on marine biotechnology and bioproducts. Metagenomics for marine secondary products https://journals.asm.org/doi/10.1128/spectrum.01501-23 In this report, long-read DNA sequencing was used to determine the biosynthetic capacity of prokaryotes in surface waters of the Yellow Sea. Marine natural product tool https://www.biorxiv.org/content/10.1101/2021.01.20.427441v1 This preprint details the development of a toolbox for identifying a broad range of biosynthetic gene cluster domains in metagenomic data. Secondary products in the Arctic Ocean https://www.microbiologyresearch.org/docserver/fulltext/mgen/7/12/mgen000731.pdf?expires=1697161491&id=id&accname=guest&checksum=C11D8730189C277E67AF0FD38348586D Here is reported metagenomic sequencing of Arctic Ocean planktonic microbiomes and mining for novel biosynthetic gene clusters of natural products. Biosynthetic potential of the global ocean https://www.nature.com/articles/s41586-022-04862-3 This study examined around 10,000 microbial genomes from marine sources that yielded approximately 40,000 biosynthetic gene cluster, most of which were characterized as being novel. From ocean to medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460513/ This review article in the journal Antibiotics summarized reports appearing after 2014 and dealing with marine bacteria and their utility for the production of novel natural products.