PANI: Ni(Leu)₂ based non-enzymatic electrochemical dopamine sensor

Abstract

Abstract In this study, metal complexes of Leucine (Leu) and Tryptophan (Trip), namely nickel(Leucine) 2 (Ni(Leu) 2 ), zinc(Leucine) 2 (Zn(Leu) 2 ), cobalt(Leucine) 2 (Co(Leu) 2 ), copper(Leucine) 2 (Cu(Leu) 2 ), nickel(Tryptophan) 2 (Ni(Trip) 2 ), zinc(Tryptophan) 2 (Zn(Trip) 2 ), cobalt(Tryptophan) 2 (Co(Trip) 2 ), and copper(Tryptophan) 2 (Cu(Trip) 2 ), were synthesized. These complexes were then utilized to fabricate nanocomposites (NCs) based on polyaniline (PANI) through a straightforward sonochemical technique. These NCs were then used to fabricate non-enzymatic electrochemical sensors for detecting dopamine (DOP). The results indicate that the PANI:Ni(Leu) 2 NCs based sensor has a high sensitivity of 28.47 μ A μ M −1 cm −2 and a low limit of detection (LOD) of 9.24 μ M. Also, the sensor was tested against fructose, glucose, lactose, and maltose. The sensitivities of the sensor against fructose, glucose, and lactose were calculated as 2.90 μ Acm −2 mM −1 , 2.14 μ Acm −2 mM −1 , 2.81 μ Acm −2 mM −1 , respectively. Due to the use of Ni(Leu) 2 composition, the DOP detection sensitivity was higher in PANI:Ni(Leu) 2 NCs which can be explained by an enhanced redox mechanism. Furthermore, PANI:Ni(Leu) 2 sensor is selectively detect DOP. The PANI:Ni(Leu) 2 NCs based sensor is a particularly promising candidate for application in biomedical test kits due to its rapid detection.