A foundation model for generalizable disease detection from retinal images

Yukun Zhou; Mark A. Chia; Siegfried K. Wagner; Murat Seçkin Ayhan; Dominic J. Williamson; Robbert Struyven; Timing Liu; Moucheng Xu; Mateo Gende; Peter Woodward-Court; Yuka Kihara; Naomi E. Allen; John Gallacher; Thomas J. Littlejohns; Tariq Aslam; Richard D. Unwin; Graeme C. Black; Panagiotis I. Sergouniotis; Denize Atan; Andrew D. Dick; Cathy Williams; Sarah Barman; Jennifer H. Barrett; Sarah Mackie; Tasanee Braithwaite; Roxana O. Carare; Sarah Ennis; Jane Whitney Gibson; Andrew Lotery; Jay Self; Usha Chakravarthy; Ruth Hogg; Euan Paterson; Jayne V. Woodside; Tünde Pető; Gareth J. McKay; Bernadette McGuinness; Paul J. Foster; Konstantinos Balaskas; Anthony P. Khawaja; Nikolas Pontikos; Jugnoo S. Rahi; Gerassimos Lascaratos; Praveen J. Patel; Michelle Chan; Sharon Chua; Alexander Day; Parul Desai; Cathy Egan; Marcus Fruttiger; David F. Garway‐Heath; Alison J. Hardcastle; Peng T. Khaw; Tony Moore; Sobha Sivaprasad; Nicholas G. Strouthidis; Dhanes Thomas; Adnan Tufail; Ananth C. Viswanathan; Bal Dhillon; Tom MacGillivray; Cathie Sudlow; Véronique Vitart; Alex S. F. Doney; Emanuele Trucco; Jeremy A. Guggeinheim; James P. Morgan; Christopher J. Hammond; Katie Williams; Pirro G. Hysi; Simon Harding; Yalin Zheng; Robert Luben; Philip J. Luthert; Zihan Sun; Martin McKibbin; Eoin O’Sullivan; Richard A. Oram; Mike Weedon; Christopher G. Owen; Alicja R. Rudnicka; Naveed Sattar; David Steel; Irene Stratton; Robyn J. Tapp; Max Yates; Axel Petzold; Savita Madhusudhan; André Altmann; Aaron Lee; Eric J. Topol; Alastair K. Denniston; Daniel C. Alexander; Pearse A. Keane

doi:10.1038/s41586-023-06555-x

JOURNAL ARTICLE

A foundation model for generalizable disease detection from retinal images

Yukun Zhou Mark A. Chia Siegfried K. Wagner Murat Seçkin Ayhan Dominic J. Williamson Robbert Struyven Timing Liu Moucheng Xu Mateo Gende Peter Woodward-Court Yuka Kihara Naomi E. Allen John Gallacher Thomas J. Littlejohns Tariq Aslam Richard D. Unwin Graeme C. Black Panagiotis I. Sergouniotis Denize Atan Andrew D. Dick Cathy Williams Sarah Barman Jennifer H. Barrett Sarah Mackie Tasanee Braithwaite Roxana O. Carare Sarah Ennis Jane Whitney Gibson Andrew Lotery Jay Self Usha Chakravarthy Ruth Hogg Euan Paterson Jayne V. Woodside Tünde Pető Gareth J. McKay Bernadette McGuinness Paul J. Foster Konstantinos Balaskas Anthony P. Khawaja Nikolas Pontikos Jugnoo S. Rahi Gerassimos Lascaratos Praveen J. Patel Michelle Chan Sharon Chua Alexander Day Parul Desai Cathy Egan Marcus Fruttiger David F. Garway‐Heath Alison J. Hardcastle Peng T. Khaw Tony Moore Sobha Sivaprasad Nicholas G. Strouthidis Dhanes Thomas Adnan Tufail Ananth C. Viswanathan Bal Dhillon Tom MacGillivray Cathie Sudlow Véronique Vitart Alex S. F. Doney Emanuele Trucco Jeremy A. Guggeinheim James P. Morgan Christopher J. Hammond Katie Williams Pirro G. Hysi Simon Harding Yalin Zheng Robert Luben Philip J. Luthert Zihan Sun Martin McKibbin Eoin O’Sullivan Richard A. Oram Mike Weedon Christopher G. Owen Alicja R. Rudnicka Naveed Sattar David Steel Irene Stratton Robyn J. Tapp Max Yates Axel Petzold Savita Madhusudhan André Altmann Aaron Lee Eric J. Topol Alastair K. Denniston Daniel C. Alexander Pearse A. Keane

Year: 2023 Journal: Nature Vol: 622 (7981)Pages: 156-163 Publisher: Nature Portfolio

DOI: 10.1038/s41586-023-06555-x

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Keywords:

Computer science Artificial intelligence Generalizability theory Retinal Machine learning Adaptation (eye) Disease Medicine Pathology Neuroscience Ophthalmology

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Retinal Imaging and Analysis

Health Sciences → Medicine → Radiology, Nuclear Medicine and Imaging

COVID-19 diagnosis using AI

Health Sciences → Medicine → Radiology, Nuclear Medicine and Imaging

Retinal and Optic Conditions

Health Sciences → Medicine → Ophthalmology

A foundation model for generalizable disease detection from retinal images

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