An endoplasmic reticulum-targeting iridium(<scp>iii</scp>) complex induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling tumor microenvironment

Yi Rong; Zhongxian Fan; Zhijie Yu; Wei Li; Han Shen; Huaiyi Huang; Xiaojuan Hao; Zizhuo Zhao; Jinquan Wang

doi:10.1039/d3qi00841j

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An endoplasmic reticulum-targeting iridium(iii) complex induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling tumor microenvironment

Yi Rong Zhongxian Fan Zhijie Yu Wei Li Han Shen Huaiyi Huang Xiaojuan Hao Zizhuo Zhao Jinquan Wang

Year: 2023 Journal: Inorganic Chemistry Frontiers Vol: 10 (18)Pages: 5278-5291 Publisher: Royal Society of Chemistry

DOI: 10.1039/d3qi00841j

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Abstract

IrC induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling the tumor microenvironment in mice.

Keywords:

Tumor microenvironment Immunotherapy Immunogenic cell death Endoplasmic reticulum Cancer research Melanoma Chemistry Cancer immunotherapy Programmed cell death Apoptosis Immune system Cell biology Tumor cells Biology Immunology Biochemistry

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Nanoplatforms for cancer theranostics

Physical Sciences → Engineering → Biomedical Engineering

Cancer Immunotherapy and Biomarkers

Health Sciences → Medicine → Oncology

Phagocytosis and Immune Regulation

Life Sciences → Immunology and Microbiology → Immunology

An endoplasmic reticulum-targeting iridium(iii) complex induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling tumor microenvironment

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