EVALUATION OF HYPOGLYCEMIC, ANTI HYPERGLYCEMIC AND ANTI HYPERLIPIDEMIC ACTIVITY OF HYDROALCHOLIC EXTRACT OF CARICA PAPAYA L.IN ALLOXAN INDUCED DIABETIC RATS

Abstract

This study was undertaken to investigate the effect of hydroalcholic extract of –Carica papaya (caricaceae) fruit on blood glucose levels in diabetic and normal rats. The diabetic was induced by using alloxan (150 mg/kg b.wt.,i.p).The hyperlipidemic was induced by using high fat diet cocktail in rats. The treatment was given at doses of 200,300,400mg/kg. b.wt. for single doses to the animal and estimating the hypoglycemic ,antihypergycemic and antihyperlipidemic was performed. After the treatment a significant reduction was observed in fasting blood glucose levels in treated diabetic rats and normal rats. Carica papaya showed significant decrease (p < 0.005) in blood glucose levels. simultaneously, the alteration in lipid metabolism was partially attenuated as evidenced by decreased Serum Total Cholesterol (TC), Triglyceride (TG) And Low-Density Lipoprotein Cholesterol (LDL) levels and by increased High-Density Lipoprotein Cholesterol (HDL) concentration in diabetic rat (p < 0.001).. These results suggest that Carica papaya L possesses anti diabetic effects in alloxan induced diabetic rats Keywords: Hypoglycemic ,Antihypergycemic , Antihyperlipidemic Carica papaya Lipid Profile, Hydroalcholic Extract