High Sensitive Voltammetric Determination of Paroxetine on Glassy Carbon Electrode Modified with Nafion/MWCNTs

Abstract

A glassy carbon electrode modified with a Nafion-MWCNT composite is shown to enable the high sensitive determination of paroxetine using differential pulse voltammetry in phosphate buffer of pH 6.5. At a preconcentration time of 15 s, the calibration graph is linear in the 0.1 μM (0.033 mg∙L-1) to 2.5 μM (0.82 mg∙L-1) concentration range with a correlation coefficient of 0.998. The detection limit at a preconcentration time of 60 s is as low as 2.6 μg∙L-1. The repeatability of the method at a 0. 16 mg∙L-1 concentration level, expressed as the RSD, is 4.1% (for n = 5). The method was successfully applied and validated by analyzing paroxetine in drug and urine samples.