Electrochemical Detection of Paracetamol Using Graphene Oxide -Modified Glassy Carbon Electrode

Abstract

A very sensitive electrochemical sensor has been developed by modification of glassy carbon electrode (GCE) with graphene oxide (GO). The electrochemical behavior of paracetamol was studied at GO/GCE using cyclic voltammetry (CV) and square-wave voltammetric techniques (SWV). A well defined oxidation peak was observed in 0.1 M KH2PO4 electrolyte solution by solid phase voltammetry. Under the CV techniques, it appears that the catalytic effect of the modification on graphene oxide GO/GCE shows higher current response as compared to bare GCE. Observed peak potential was shifted to less positive value by about 220 mV and current was significantly enhanced by about 2 folds. Square-wave voltammetry showed higher sensitive response than CV techniques, where current was significantly enhanced by more than 2 folds. Under the optimum conditions, the oxidation peak current of paracetamol varied linearly with concentration over a wide range of 5 x 10-8 mol L-1 to 1 x10-6 mol L-1 and the detection limit of this method was as low as 4.9 x 10-8 M.