Potentiometric Assay of Antipsychotic Drug (Ziprasidone Hydrochloride) in Pharmaceuticals, Serum and Urine

Abstract

The membranes of ziprasidone hydrochloride-tetraphenyl borate, (Zp-TPB), chlorophenyl borate (Zp-ClPB), phosphotungstate (Zp3-PT), ion associations as molecular recognition reagent dispersed in PVC matrix with dibutylphthalate as plasticizer have been proposed for quantification of ziprasidone hydrochloride. The performance characteristics revealed a fast, stable and liner response for ziprasidone over the concentration ranges of 8.5 ×10-6-1.0 ×10-2 M, 3.9 ×10-6-1.0 ×10-2M, 7.7 ×10-7 1.0 × 10-2 M ZpCl with cationic slopes of 57.0, 56.0, 58.5 mV/decade respectively. The solubility product of the ion-pair and the formation constant of the precipitation reaction leading to the ion-pair formation were determined conductometrically. The potentiometric determination of ziprasidone hydrochloride ion in different pharmaceutical preparations and biological fluids has been achieved without any interference from various excipients and diluents commonly used in drug formulations. Validation of the method shows suitability of the proposed electrodes for use in the quality control assessment of ziprasidone hydrochloride. The proposed potentiometric methods offer the advantages of high–throughput determination, simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.