Application of silk fibroin composite scaffold in bone tissue engineering

Abstract

As a natural protein, silk protein has superior biocompatibility, biodegradability and mechanical properties, and can be used in different forms for bone tissue repair in bone tissue engineering as a good biomaterial. The treatment of bone defect has always been a serious challenge for orthopedic surgeons. However, the traditional treatment of bone defect is autologous bone and bone allograft, with limited source and secondary injury with sampling site; the allograft faces ethical problems, rejection, and viral transmission risk. Tissue engineering is an important means to solve tissue and organ defects. It establishes a three-dimensional space complex composed of cells and biological materials and fills the defects, so as to repair the effect Bone tissue scaffold with filim protein plays a huge role in orthopedics, and is expected to bring good news to more patients with bone diseases in the future. In this paper, we review the structural characteristics, biological properties and applications of filamentous proteins in bone tissue engineering.